Publications


CRISPR-related publications


Osei-Amponsa V, Sridharan V, Tandon M, Evans CN, Klarmann K, Cheng KT, Lack J, Chari R, Walters KJ. Impact of Losing hRpn13 Pru or UCHL5 on Proteasome Clearance of Ubiquitinated Proteins and RA190 Cytotoxicity. Molecular and Cellular Biology MCB.00122-20. doi: 10.1128/MCB.00122-20. PMID: 32631902

Choi J, Zhang T, Vu A, Ablain J, Makowski MM, Colli LM, Xu M, Hennessey RC, Yin J, Rothschild H, Gräwe C, Kovacs MA, Funderburk KM, Brossard M, Taylor J, Pasaniuc B, Chari R, Chanock SJ, Hoggart CJ, Demenais F, Barrett JH, Law MH, Iles MM, Yu K, Vermeulen M, Zon LI, Brown KM (2020). Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma. Nature Communications 11(1):2718. doi: 10.1038/s41467-020-16590-1. PMID: 32483191

Rathkey D, Khanal M, Murai J, Zhang J, Sengupta M, Jiang Q, Morrow B, Evans CN, Chari R, Fetsch P, Chung HJ, Xi L, Roth M, Filie A, Raffeld M, Thomas A, Pommier Y, Hassan R (2020). Sensitivity of Mesothelioma Cells to PARP Inhibitors Is Not Dependent on BAP1 but Is Enhanced by Temozolomide in Cells With High-Schlafen 11 and Low-O6-methylguanine-DNA Methyltransferase Expression. Journal of Thoracic Oncology 15(5):843-859. doi: 10.1016/j.jtho.2020.01.012. PMID: 32004714

Buel GR, Chen X, Chari R, O'Neill MJ, Ebelle DL, Jenkins C, Sridharan V, Tarasov SG, Tarasova NI, Andresson T, Walters KJ (2020). Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10. Nature Communications 11(1):1291. doi: 10.1038/s41467-020-15073-7. PMID: 32157086

Chari R, Church GM (2017). Beyond editing to writing large genomes. Nature Reviews Genetics 18(12):749-760. PMID: 28852223

Chari R, Chavez A, Yeo NC, Church G (2017). sgRNA Scorer 2.0: A Species-Independent Model To Predict CRISPR/Cas9 Activity. ACS Synthetic Biology 6(5):902-904. PMID: 28146356

Chavez A, Tuttle M, Pruitt BW, Ewen-Campen B, Chari R, Ter-Ovanesyan D, Haque SJ, Cecchi RJ, Kowal EJ, Buchthal J, Housden BE, Perrimon N, Collins JJ, Church G (2016). Comparison of Cas9 activators in multiple species. Nature Methods 13(7):563-7. PMID: 27214048

Feng J, Jester BW, Tinberg CE, Mandell DJ, Antunes MS, Chari R, Morey KJ, Rios X, Medford JI, Church GM, Fields S, Baker D (2015). A general strategy to construct small molecule biosensors in eukaryotes. eLife. pii: e10606. PMID: 26714111

Kiani S, Chavez A, Tuttle M, Hall RN, Chari R, Ter-Ovanesyan D, Qian J, Pruitt BW, Beal J, Vora S, Buchthal J, Kowal EJ, Ebrahimkhani MR, Collins JJ, Weiss R, Church G (2015). Cas9 gRNA engineering for genome editing, activation and repression. Nature Methods. 12(11):1051-4. PMID: 26344044

Chari R, Mali P, Moosburner M, Church GM (2015). Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach. Nature Methods. 12(9):823-826. PMID: 26167643

Yang L, Grishin D, Wang G, Aach J, Zhang CZ, Chari R, Homsy J, Cai X, Zhao Y, Fan JB, Seidman C, Seidman J, Pu W, Church G (2014). Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells. Nature Communications. PMID: 25425480


Any suggestions or comments can be e-mailed to sgrnascorer 'at' cancer 'dot' gov

Updated July 11th, 2020